vOTU preferences for different di-Ub linkages. John V. Dzimianski Brianna S. Beldon Courtney M. Daczkowski Octavia Y. Goodwin Florine E. M. Scholte Éric Bergeron Scott D. Pegan 10.1371/journal.ppat.1007515.g003 https://plos.figshare.com/articles/figure/vOTU_preferences_for_different_di-Ub_linkages_/7575221 <p>(A) Activity towards K48, K63, and K11 linked di-Ub FRET-TAMRA substrates. Values shown are the mean ± standard deviation of two independent experiments. (B) Gel cleavage assay of unlabeled di-Ub, visualized by Commassie Blue staining. (C) Summary of currently investigated vOTU di-Ub activity (present study and [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1007515#ppat.1007515.ref032" target="_blank">32</a>]).</p> 2019-01-10 19:09:59 novel X-ray crystal structures Crimean-Congo hemorrhagic fever virus Recent genomic characterization ISG 15 fluorogenic substrates Hughes orthonairovirus species Nairoviridae family vOTU substrate preferences DUB deubiquitinase activity Post-translational modification gene product 15 nairovirus genomic diversity tumor domain protease