Brubaker, Douglas K. Proctor, Elizabeth A. M. Haigis, Kevin Lauffenburger, Douglas A. Delineation of four categories of translation problems, those of generalizing insights from model systems to human <i>in vivo</i> contexts. <p>The coverage and resolution of the available data determines the category. Categories one through three are potentially approachable by data integration of model system and human datasets and semi-supervised learning approaches.</p> vivo disease processes;model systems;mouse models;approach;36 transcriptomic case studies;mouse model experiments;mouse experiments 2019-01-10
    https://plos.figshare.com/articles/figure/Delineation_of_four_categories_of_translation_problems_those_of_generalizing_insights_from_model_systems_to_human_i_in_vivo_i_contexts_/7575188
10.1371/journal.pcbi.1006286.g004