%0 Figure %A N. Heestand, Bree %A Shen, Yidong %A Liu, Wei %A B. Magner, Daniel %A Storm, Nadia %A Meharg, Caroline %A Habermann, Bianca %A Antebi, Adam %D 2013 %T nhr-62 specifically regulates DR-induced longevity. %U https://plos.figshare.com/articles/figure/_nhr_62_specifically_regulates_DR_induced_longevity_/755098 %R 10.1371/journal.pgen.1003651.g002 %2 https://plos.figshare.com/ndownloader/files/1131022 %K genetics %K gene expression %K RNA interference %K Animal genetics %K Gene function %K Genetic screens %K Model organisms %K Animal models %K Caenorhabditis elegans %K Population biology %K aging %K regulates %K dr-induced %X

(A) Survivorship curves for wild-type (N2), eat-2(ad465), nhr-62(tm1818), eat-2;nhr-62, and eat-2;nhr-62(dhEx627). Extra chromosomal array dhEx627 (carrying a wild-type nhr-62) in eat-2;nhr-62 resulted in a significant increase in lifespan compared to both nhr-62(tm1818) and eat-2;nhr-62 mutants (p<0.001). (B) Wild-type (N2) worms with dhEx627 exhibited a significant increase in lifespan compared to wild-type (p<0.001). See Figure S2 for physiologic traits of overexpression. (C,D) Both wild-type (N2) and nhr-62(tm1818) worms fed daf-2 RNAi or cco-1 RNAi had a significant increase in lifespan when compared to controls (p<0.001). (E) BDR curve for wild-type (N2) and nhr-62(tm1818) worms. The lifespan of wild-type and nhr-62(tm1818) were not different at the three most concentrated food dilutions, but were significantly different at the remaining 7 dilutions (p<0.001). (F) Survivorship curves for wild-type (N2) and nhr-62(tm1818) fed either 6.45×108 CFU/ml or 3.23×108 CFU/ml. p-values calculated by the log-rank test.

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