S. Sahlberg, Anna Ruuska, Marja Granfors, Kaisa A. Penttinen, Markus PKR inhibition effects on HuR expression and regulation in U937 monocytic cells. <p>Full length HuR (36 kDa) and HuR cleavage products (CP1; 24 kDa and CP2; 8 kDa) in LPS-stimulated (A) and <i>Salmonella enteritidis</i>-infected (B) PKR inhibitor (PKR+)- or negative control for PKR inhibition (PKR-)-treated U937 Mock, B27g, H9F and E45M cells at 5 h time point. Expression of HuR was determined by SDS-PAGE and Western blotting. HSPA8 was used as a loading control. Results from densitometric analysis of five independent experiments are shown in diagram. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070377#s2" target="_blank">Materials and Methods</a> for details. * = P-value ≤0.06 for HuR, <sup>‡</sup> = P-value ≤0.06 for CP1 and <sup>†</sup> = P-value ≤0.06 for CP2 versus untreated sample at the respective cell line.</p> immunology;Immune cells;monocytes;Immune system;cytokines;Immune response;Major histocompatibility complex;microbiology;Bacterial pathogens;Salmonella;Host-pathogen interaction;Molecular cell biology;cytometry;flow cytometry;Signal transduction;Signaling cascades;MAPK signaling cascades;Protein kinase signaling cascade;Stress signaling cascade;Cellular stress responses;Infectious diseases;Bacterial diseases;inhibition;hur;u937;monocytic 2013-07-22
    https://plos.figshare.com/articles/figure/_PKR_inhibition_effects_on_HuR_expression_and_regulation_in_U937_monocytic_cells_/750326
10.1371/journal.pone.0070377.g002