%0 Figure %A Maharana, Jitendra %A Panda, Debashis %A De, Sachinandan %D 2018 %T Overview of structural transitions facilitated by NLRP1/3/Nlrc4NACHT models in response to ATP. %U https://plos.figshare.com/articles/figure/Overview_of_structural_transitions_facilitated_by_NLRP1_3_Nlrc4_sup_NACHT_sup_models_in_response_to_ATP_/7493498 %R 10.1371/journal.pone.0209420.g005 %2 https://plos.figshare.com/ndownloader/files/13886960 %K ATP-Mg %K oligomerization domain %K NLRP-signaling mechanism %K ATPase superfamily %K PRR %K inflammasome activity %K sensor-adaptor-effector interactions %K C-terminal end %K novel inhibitors %K NLRP NACHT models %K residue %K ATP-binding pocket %K NLRP-NACHT 3 D models %K NOD %K LRR %K cytosolic pattern recognition receptors %K bioinformatics approaches %K ADP %K mutagenesis data %K protein modeling %K AAA %K pathogen recognition %K bioinformatics approaches Nucleotide-binding %K EBD %K PhhC W motif %K dynamics simulations %K G F xxxxRxx Y F motif %K structural-dynamic features %X

(A) Superimposed view of open-close state of Nlrc4NACHT domain; the inactive/closed structure is displayed in gray cartoon and the active/open state structure is presented in yellow cartoon; the hinge region is marked red circle. (B) Comparative view backbone RMSD and Rg of ATP-Mg2+ bound NACHT domains in monomeric and dimeric condition. (C) Superimposed view of NLRP/Nlrc4NACHT models showed structural transitions (pre-MD structures are presented in grey cartoon and post MD structure in colored cartoon).

%I PLOS ONE