10.1371/journal.pone.0208042.g003
Ruth F. Dubin
Ruth F.
Dubin
Mary Whooley
Mary
Whooley
Alexander Pico
Alexander
Pico
Peter Ganz
Peter
Ganz
Nelson B. Schiller
Nelson
B. Schiller
Craig Meyer
Craig
Meyer
Mapping Clinical Outcome Information to the Complement and Coagulation Pathway (See Attached File).
Public Library of Science
2018
CKD
NOTCH
HR
Soul Study Background Patients
heart failure
Soul Study
heart failure hospitalization
kidney disease
neurogenis locus notch homolog protein 1
adjudicated HF events
Cox survival analyses
2018-12-17 18:26:26
Figure
https://plos.figshare.com/articles/figure/Mapping_Clinical_Outcome_Information_to_the_Complement_and_Coagulation_Pathway_See_Attached_File_/7473464
<p>The Coagulation and Complement pathway is shown in this diagram, (source: <a href="https://www.wikipathways.org/index.php/Pathway:WP558" target="_blank">https://www.wikipathways.org/index.php/Pathway:WP558</a>.) Colored boxes represent results from random forest survival analyses. Gray boxes represent proteins associated with heart failure when the full sample was analyzed. Green boxes represent proteins that were associated with HF after analysis of the non-CKD sub-group. Yellow boxes represent proteins associated with HF after analysis of the CKD sub-group, including F7(Coagulation factor VII precursor), SERPINA1(Alpha-1-antitrypsin precursor), PROS1(Vitamin K dependent protein S precursor), PLAUR(Urokinase plasminogen activator surface receptor), KLKB1(Plasma kallikrein precursor), Complement(C)6, C7, C8-gamma chain, C9. Coagulation factors 3, 8, 12 and MASP2 were not measured.</p>