10.1371/journal.pntd.0006980.g004 James A. Thomas James A. Thomas Nicola Baker Nicola Baker Sebastian Hutchinson Sebastian Hutchinson Caia Dominicus Caia Dominicus Anna Trenaman Anna Trenaman Lucy Glover Lucy Glover Sam Alsford Sam Alsford David Horn David Horn Assessment of mitochondrial and lysosomal phenotypes. Public Library of Science 2018 mitotic arrest DNA damage flow cytometry ornithine decarboxylase antitrypanosomal drug mode-of-action mitochondrial membrane mitochondrial protein abundance antitrypanosomal drug MoA DNA replication antitrypanosomal drugs melarsoprol-induced mitotic defect mitogen-activated protein-kinases kinetoplast DNA HAT drugs antitrypanosomal drugs perturb novel insight terminal dUTP nick end labelling cell cycle phases image analysis 2018-11-26 19:48:08 Figure https://plos.figshare.com/articles/figure/Assessment_of_mitochondrial_and_lysosomal_phenotypes_/7382285 <p>(<b>A</b>) The microscopy images show examples of the Mitotracker signals. Percentage of cells positive for the typical ‘extended’ Mitotracker signal are shown. *, <i>P</i> < 0.05 from Students <i>t</i>-test. (<b>B</b>) The microscopy images show examples of the Lysotracker signals observed in untreated and suramin-treated cells. Percentage of cells positive for Lysotracker signal are shown. Other details as in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006980#pntd.0006980.g002" target="_blank">Fig 2A</a>; error bars, SD; N = 2; scale bars, 5 μm except for suramin-treated cells, which are 10 μm.</p>