10.1371/journal.pntd.0006980.g004
James A. Thomas
James A.
Thomas
Nicola Baker
Nicola
Baker
Sebastian Hutchinson
Sebastian
Hutchinson
Caia Dominicus
Caia
Dominicus
Anna Trenaman
Anna
Trenaman
Lucy Glover
Lucy
Glover
Sam Alsford
Sam
Alsford
David Horn
David
Horn
Assessment of mitochondrial and lysosomal phenotypes.
Public Library of Science
2018
mitotic arrest
DNA damage
flow cytometry
ornithine decarboxylase
antitrypanosomal drug mode-of-action
mitochondrial membrane
mitochondrial protein abundance
antitrypanosomal drug MoA
DNA replication
antitrypanosomal drugs
melarsoprol-induced mitotic defect
mitogen-activated protein-kinases
kinetoplast DNA
HAT drugs
antitrypanosomal drugs perturb
novel insight
terminal dUTP nick end labelling
cell cycle phases
image analysis
2018-11-26 19:48:08
Figure
https://plos.figshare.com/articles/figure/Assessment_of_mitochondrial_and_lysosomal_phenotypes_/7382285
<p>(<b>A</b>) The microscopy images show examples of the Mitotracker signals. Percentage of cells positive for the typical ‘extended’ Mitotracker signal are shown. *, <i>P</i> < 0.05 from Students <i>t</i>-test. (<b>B</b>) The microscopy images show examples of the Lysotracker signals observed in untreated and suramin-treated cells. Percentage of cells positive for Lysotracker signal are shown. Other details as in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006980#pntd.0006980.g002" target="_blank">Fig 2A</a>; error bars, SD; N = 2; scale bars, 5 μm except for suramin-treated cells, which are 10 μm.</p>