%0 Figure %A Baeten, Laurie A. %A K. Podell, Brendan %A Sluder, Ann E. %A Garritsen, Anja %A Bowen, Richard A. %A C. Poznansky, Mark %D 2018 %T Zone of erythema and histopathological scores after antigenic challenge of i.n. sensitized guinea pigs. %U https://plos.figshare.com/articles/figure/Zone_of_erythema_and_histopathological_scores_after_antigenic_challenge_of_i_n_sensitized_guinea_pigs_/7202966 %R 10.1371/journal.pone.0205882.g009 %2 https://plos.figshare.com/ndownloader/files/13259156 %K Standardized guinea pig model %K 21 days post-sensitization %K 42 days %K Intradermal skin testing %K ruminant vaccine Coxevac %K guinea pig model %K Q fever vaccine reactogenicity %K challenge %K exposure-related reactogenic responses %K intradermal %K guinea pig hypersensitivity models %X

Data are presented for each inoculation group (saline (n = 4), Cb9M: C. burnetii Nine Mile, i.n.: intranasal, (n = 9)). Coxevac challenge (2 μg delivered i.d.) was performed at day 42 p.i. (A) Histopathological scoring (0–5) is as noted in Table 1, (B) zone of erythema (mm). Error bars represent group mean and standard deviations. **Group means were statistically different for both histological scores and erythema (P value 0.002, 0.002 respectively, assessed by one-sided t test).

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