Baeten, Laurie A. K. Podell, Brendan Sluder, Ann E. Garritsen, Anja Bowen, Richard A. C. Poznansky, Mark Reactogenicity to vaccine in sensitized vs unsensitized guinea pigs. <p>Images are representative of guinea pigs inoculated i.n. with <i>C</i>. <i>burnetii</i> (C and D) or unsensitized (saline) (A and B), then challenged with a 2 μg intradermal dose of vaccine (Coxevac) at day 42 p.i.. A) Inflammation at day 7 p.c. in unsensitized guinea pig is multifocal (arrows) and limited to the deep dermis. B) Inflammation at day 21 p.c. in unsensitized guinea pig is similar to day 7 (arrow). C) More severe inflammation with extension through the dermis (arrows) at day 7 p.c. in <i>Cb</i>9M-sensitized guinea pig. D) Progression of inflammation in <i>Cb</i>9M-sensitized guinea pig at day 21 p.c. (arrows) with increased frequency of neutrophils and presence of microabscesses (arrowheads).</p> Standardized guinea pig model;21 days post-sensitization;42 days;Intradermal skin testing;ruminant vaccine Coxevac;guinea pig model;Q fever vaccine reactogenicity;challenge;exposure-related reactogenic responses;intradermal;guinea pig hypersensitivity models 2018-10-12
    https://plos.figshare.com/articles/figure/Reactogenicity_to_vaccine_in_sensitized_vs_unsensitized_guinea_pigs_/7202960
10.1371/journal.pone.0205882.g007