Simulated dataset. Flora Alarcon Violaine Planté-Bordeneuve Malin Olsson Grégory Nuel 10.1371/journal.pone.0203860.g001 https://plos.figshare.com/articles/figure/Simulated_dataset_/7129160 <p>Reference and estimation of the survival function <i>S</i>(<i>t</i>) for carriers with 95% point-wise confidence intervals (dashed lines). A total of <i>n</i> = 3,285 (1,641 males and 1,644 females) individuals including 441 affected and 319 genotyped. Left: simulation and estimation without gender effect. Right: simulation and estimation with a proportional protective effect for females (gender = 2).</p> 2018-09-25 17:31:26 EM survival function Weibull survival Bayesian networks family samples hazard model factors effects prevention strategies survival procedures pedigrees data mutation carriers Kaplan-Meier non-parametric estimates mutation carriers management mutation carrier survival estimates survival function estimation risk assessment Non-parametric estimation