Nishida, Miwa Saegusa, Jun Tanaka, Shino Morinobu, Akio Osteoclasts generated with S100A12 exhibit increased bone resorption. <p>Osteoclasts were generated on a bone resorption assay plate with or without S100A12 (1,000 ng/ml) for 16 days. The resorption lacunae were examined by microscopy. <b>(A)</b> The percentage of the resorbed area (i.e., bright areas in <b>(B)</b>) was quantified and expressed as the mean and SD of 3 independent experiments. * = <i>p</i> < 0.05; ** = <i>p</i> < 0.01. <b>(B)</b> Representative images of resorption pit formation (original magnification × 200).</p> CTSK;osteoclast differentiation;CA 2. Blocking RAGE;expression;ACP;TLR;tumor necrosis factor;ITG;S 100 family member;low-molecular-weight calcium-binding protein;role;TNF;IL;RANKL;S 100A administration;CALCR;S 100A 2018-09-20
    https://plos.figshare.com/articles/figure/Osteoclasts_generated_with_S100A12_exhibit_increased_bone_resorption_/7114022
10.1371/journal.pone.0204140.g002