%0 Figure %A Waitumbi, John N. %A M. Kifude, Carolyne %A W. Hunja, Carol %A R. Ogutu, Bernhards %D 2018 %T Dot plot showing geometric mean parasite densities within the 25%, 50%, 75% and >75% quartile ranges for boys and girls of HbAS genotype. %U https://plos.figshare.com/articles/figure/Dot_plot_showing_geometric_mean_parasite_densities_within_the_25_50_75_and_75_quartile_ranges_for_boys_and_girls_of_HbAS_genotype_/7074089 %R 10.1371/journal.pone.0203455.g002 %2 https://plos.figshare.com/ndownloader/files/13007114 %K HPLC %K phase 2 b malaria vaccine trial %K G 6PD deficiency typing %K PCR %K sickling phenomenon %K HbAS %K Hb S %K G 6PD genotypes %K malaria parasite load %K SD %K G 6PD deficiency %K intra-erythrocytic deoxyhemoglobin S %X

This data came from multiple sick visits with the 265 days follow-up period. Due to the high variability and with a wide range of parasitemia data, analysis was done at different distribution quartiles. At all the quartile ranges 25%, 50% and 75% (panels A, B and C respectively) the parasite geometric mean for females of HbAS/αα/αα genotype was much higher than for males. As shown in panel C, the median parasite density within the third quartile was two times higher in females of HbAS/αα/αα genotype (3,118, 95% CI: 1779–5465) than for males (1,676, 95% CI: I752-3733). This trend was maintained across the ordered α-thalassemia genotypes (Kurskal-Wallis; 0.0422). A second loss of α+-thal gene increased the parasite load even further. Each dot represents parasitemia from a sick visit from the patients.

%I PLOS ONE