The MrBayes majority-rule consensus tree reveals a distinct phylogenetic relationship between Cryptococcal Mpr1 and other M36 family members.
Sarisa Na Pombejra
Mantana Jamklang
John P. Uhrig
Kiem Vu
Angie Gelli
10.1371/journal.pone.0203020.g001
https://plos.figshare.com/articles/figure/The_MrBayes_majority-rule_consensus_tree_reveals_a_distinct_phylogenetic_relationship_between_Cryptococcal_Mpr1_and_other_M36_family_members_/7031195
<p>The MrBayes tree is based on ClustalW2 amino acid sequence alignments of CnMPR1 and other M36 family members and obtained from searching the HMMER web server (hmmer.janelia.org). The Bayesian tree reveals a distinct phylogenetic relationship between Mpr1 in Cryptococcus species and M36 family members in other fungi. An Mpr1 homolog was identified in the closely related basidiomycete <i>Tremella mesenterica</i>, however, Mpr1 clusters separately from the rest of the M36 family. Posterior probability values are shown as node labels. Well supported nodes indicated by a “1” with maximum likelihood bootstrap (BS) support >80.</p>
2018-08-30 17:46:36
prodomain cleavage sites
Mpr 1
structure-function analysis
Mpr 1 protein
Mpr 1 activity
M 36 class
BBB
blood-brain barrier Cryptococcal meningoencephalitis
cryptococcal meningoencephalitis-related deaths
Mpr 1 metalloprotease determinants
CNS