10.1371/journal.pone.0063606.g007 Junko Kosaka Junko Kosaka Hiroshi Morimatsu Hiroshi Morimatsu Toru Takahashi Toru Takahashi Hiroko Shimizu Hiroko Shimizu Susumu Kawanishi Susumu Kawanishi Emiko Omori Emiko Omori Yasumasa Endo Yasumasa Endo Naofumi Tamaki Naofumi Tamaki Manabu Morita Manabu Morita Kiyoshi Morita Kiyoshi Morita Effect of BV administration after hemorrhagic shock and resuscitation (HSR) in the lungs. Public Library of Science 2013 Biochemistry drug discovery Molecular cell biology Cellular stress responses Clinical immunology immunity inflammation Critical care and emergency medicine Drugs and devices Clinical pharmacology Drug research and development Pulmonology bv hemorrhagic resuscitation 2013-05-07 02:25:10 Figure https://plos.figshare.com/articles/figure/_Effect_of_BV_administration_after_hemorrhagic_shock_and_resuscitation_HSR_in_the_lungs_/698710 <p>The rats were randomly divided into two groups: a HSR/Vehicle group, which was administered vehicle after HSR, and a HSR/BV group, which was administered BV after HSR. BV (35 mg/kg) or vehicle was injected via the femoral vein after resuscitation. (<b>A</b>) Representative images from five independent experiments (hematoxylin–eosin staining, original magnification ×200, scale bar  = 100 µm). (<b>B</b>) lung histopathological score 12 h after HSR. (<b>C</b>) Mitochondrial 8-OHdG levels in the lungs 3 h after HSR. Data are presented as means ± standard deviation (n = 5 per group). Statistical analysis was performed using Student’s t-test. <sup>*</sup>p<0.05 vs. HSR/Vehicle.</p>