Lipid accumulation was not affected by deficiency of macrophage CD40.
Suzanne A. B. M. Aarts
Myrthe E. Reiche
Myrthe den Toom
Linda Beckers
Marion J. J. Gijbels
Norbert Gerdes
Menno P. J. de Winther
Esther Lutgens
10.1371/journal.pone.0202150.g005
https://plos.figshare.com/articles/figure/Lipid_accumulation_was_not_affected_by_deficiency_of_macrophage_CD40_/6956876
<p><b>(A)</b> Liver weight (n = 16 for HFD and n = 7 for SFD) <b>(B)</b> Quantification of oil-red-o stained area in the liver (n = 16 for HFD and n = 7 for SFD). <b>(C)</b> Liver TG levels (n = 6-9/group). <b>(D)</b> Liver total cholesterol levels (n = 6-9/group). <b>(E)</b> Representative pictures of ORO staining of the livers. <b>(F)</b> Histopathological score of liver steatosis (n = 16/group). <b>(G)</b>. Plasma ALT levels (n = 7-9/group). <b>(H)</b>. Plasma AST levels (n = 7-9/group). <b>(I)</b> mRNA expression of liver lipid metabolism genes (n = 7-10/group). Data is presented as mean ± SEM. N.D. means ‘not detectable’.</p>
2018-08-10 17:39:43
adipose tissue leukocyte infiltration
WT
40L
Macrophage CD 40
SFD
adipose tissue inflammation
40-CD
ameliorates adipose tissue inflammation
insulin resistance
HFD
CD 40 flfl LysM cre
increases insulin sensitivity
macrophage CD 40
adipose tissue weight
DIO
plasma adiponectin levels
triglyceride levels
macrophage CD 40. CD 40 flfl LysM cre mice
adipose tissue cytokine levels