Adipose tissue inflammation is slightly increased in macrophage CD40 deficient mice without resulting in altered cytokine release.
Suzanne A. B. M. Aarts
Myrthe E. Reiche
Myrthe den Toom
Linda Beckers
Marion J. J. Gijbels
Norbert Gerdes
Menno P. J. de Winther
Esther Lutgens
10.1371/journal.pone.0202150.g004
https://plos.figshare.com/articles/figure/Adipose_tissue_inflammation_is_slightly_increased_in_macrophage_CD40_deficient_mice_without_resulting_in_altered_cytokine_release_/6956870
<p><b>(A)</b> Quantification of CD45 staining for leukocytes of EpAT (n = 16 for HFD and n = 7 for SFD). <b>(B)</b> Quantification of Mac3 staining for macrophages in EpAT (n = 16 for HFD and n = 7 for SFD). <b>(C)</b> Quantification of CD3<sup>+</sup> staining for T cells in EpAT (n = 16 for HFD and n = 7 for SFD). <b>(D)</b> Flow cytometric analysis of leukocyte subsets in EpAT, as % of total CD45<sup>+</sup> leukocytes (n = 7-9/group). <b>(E)</b> mRNA expression of inflammatory markers in EpAT (n = 7-9/group). Data is presented as mean ± SEM.</p>
2018-08-10 17:39:43
adipose tissue leukocyte infiltration
WT
40L
Macrophage CD 40
SFD
adipose tissue inflammation
40-CD
ameliorates adipose tissue inflammation
insulin resistance
HFD
CD 40 flfl LysM cre
increases insulin sensitivity
macrophage CD 40
adipose tissue weight
DIO
plasma adiponectin levels
triglyceride levels
macrophage CD 40. CD 40 flfl LysM cre mice
adipose tissue cytokine levels