CD40<sup>fl/fl</sup>LysM<sup>cre</sup> mice have similar glucose tolerance and insulin resistance than their WT controls.
Suzanne A. B. M. Aarts
Myrthe E. Reiche
Myrthe den Toom
Linda Beckers
Marion J. J. Gijbels
Norbert Gerdes
Menno P. J. de Winther
Esther Lutgens
10.1371/journal.pone.0202150.g002
https://plos.figshare.com/articles/figure/CD40_sup_fl_fl_sup_LysM_sup_cre_sup_mice_have_similar_glucose_tolerance_and_insulin_resistance_than_their_WT_controls_/6956861
<p><b>(A)</b> Glucose tolerance test (n = 6–9 mice/group). <b>(B)</b> Insulin tolerance test (n = 6–16 mice/group). <b>(C)</b> Fasted glucose levels (n = 6–9 mice/group). <b>(D)</b> Fasted insulin levels (n = 5–8 mice/group). Data is presented as mean ± SEM.</p>
2018-08-10 17:39:43
adipose tissue leukocyte infiltration
WT
40L
Macrophage CD 40
SFD
adipose tissue inflammation
40-CD
ameliorates adipose tissue inflammation
insulin resistance
HFD
CD 40 flfl LysM cre
increases insulin sensitivity
macrophage CD 40
adipose tissue weight
DIO
plasma adiponectin levels
triglyceride levels
macrophage CD 40. CD 40 flfl LysM cre mice
adipose tissue cytokine levels