Differential cell permeability of amiloride derivatives.
Leonardo J. Leon
Nagarekha Pasupuleti
Fredric Gorin
Kermit L. Carraway III
10.1371/journal.pone.0063038.g001
https://plos.figshare.com/articles/figure/_Differential_cell_permeability_of_amiloride_derivatives_/694774
<p>(<b>A</b>) The structures of amiloride and the two C(5) derivatives employed in these studies are depicted. The Bn in the UCD38B structure refers to a benzyl group. (<b>B</b>) MDA-MB-231 cells were incubated with vehicle control or 250 µM amiloride, UCD74A or UCD38B for 10 minutes and rinsed with PBS. Treated cells were then imaged by brightfield (upper panels) or fluorescence (lower panels) microscopy, the fluorescence intensities of 20 randomly selected cells were quantified, and averages with standard error are indicated.</p>
2013-04-30 01:19:34
Biochemistry
drug discovery
Small molecules
Molecular cell biology
Cell death
Cell growth
Cellular stress responses
Obstetrics and gynecology
breast cancer
oncology
Cancer treatment
Chemotherapy and drug treatment
Cancers and neoplasms
Breast tumors
permeability
amiloride