%0 Figure %A Yan, Cong %A Ding, Xinchun %A Wu, Lingyan %A Yu, Menggang %A Qu, Peng %A Du, Hong %D 2013 %T ELISA analyses of CHI3L1 protein in BALF and serum of systemic inflammation-induced lung tumor mice. %U https://plos.figshare.com/articles/figure/_ELISA_analyses_of_CHI3L1_protein_in_BALF_and_serum_of_systemic_inflammation_induced_lung_tumor_mice_/687872 %R 10.1371/journal.pone.0061984.g004 %2 https://plos.figshare.com/ndownloader/files/1031394 %K Biochemistry %K histology %K immunology %K oncology %K Cancer detection and diagnosis %K Early detection %K chi3l1 %K balf %K serum %K systemic %K inflammation-induced %X

Left: CHI3L1 protein concentrations in BALF and serum of doxycycline-treated and untreated bitransgenic mice. Right: ROC (Receiver Operating Characteristic) curve analyses to determine the area under the curve (AUC). Dox-: doxycycline-untreated mice; Dox+: doxycycline-treated mice without showing lung tumor; Cancer, doxycycline-treated mice with lung tumor. A) c-fms-rtTA/(TetO)7-CMV-MMP12 mice. Mean ± SD in BALF (n>7), DOX -: 17.7±13.8, DOX +: 42.1±67.9, Cancer: 70.9±36.5. Mean ± SD in serum (n>7), DOX -: 39.1±25.6, DOX +: 57.7±55.5, Cancer: 232.3±110.6. The gray lines represent the mean values; B) c-fms-rtTA/(TetO)7-CMV-Api6 mice. Mean ± SD in BALF (n>6), DOX -: 69.6±16.6, DOX +: 73.2±28.1, Cancer: 189.9±47.2. Mean ± SD in serum (n>6), DOX -: 25.2±7.3, DOX +: 21.0±11.7, Cancer: 69.5±19.1. The gray lines represent the mean values.

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