DCA increases hepatic ER stress signaling and decreases hepatic insulin signaling.
Karolina E. Zaborska
Seon A. Lee
Darline Garribay
Eumee Cha
Bethany P. Cummings
10.1371/journal.pone.0200908.g003
https://plos.figshare.com/articles/figure/DCA_increases_hepatic_ER_stress_signaling_and_decreases_hepatic_insulin_signaling_/6878474
<p>Phosphorylated to total IRE (A) and spliced XBP1 (sXBP1) expression normalized to tubulin (B). BiP (C) and TNFα (D) expression normalized to tubulin and phosphorylated to total Akt expression (E). Data are expressed as mean ± SEM, *<i>P</i><0.05, **<i>P</i><0.01 by Student’s t-test, <i>n</i> = 6 per group.</p>
2018-07-30 17:31:23
hepatic ER homeostasis
C 57BL mice
mice Bile acids
ER stress
attenuate hepatic endoplasmic reticulum
DCA
Deoxycholic acid supplementation impairs glucose homeostasis
bile acid subtype
body glucose regulation
hepatic insulin
glucose regulation
bile acid subtypes
body glucose homeostasis
insulin tolerance testing
bile acid profile
hepatic ER stress