%0 Generic %A Mugglin, Catrina %A Wandeler, Gilles %A Estill, Janne %A Egger, Matthias %A Bender, Nicole %A Davies, Mary-Ann %A Keiser, Olivia %D 2013 %T Characteristics of studies included in review, first CD4 cell count measurement after HIV diagnosis and mortality rates prior to initiation of antiretroviral therapy (ART). %U https://plos.figshare.com/articles/dataset/_Characteristics_of_studies_included_in_review_first_CD4_cell_count_measurement_after_HIV_diagnosis_and_mortality_rates_prior_to_initiation_of_antiretroviral_therapy_ART_/665351 %R 10.1371/journal.pone.0056446.t001 %2 https://plos.figshare.com/ndownloader/files/1004733 %K studies %K included %K cd4 %K hiv %K rates %K initiation %K antiretroviral %X
n.r. not reported.
*Immunological and clinical eligibility criteria for ART initiation were the following:
WHO 2003 guidelines [33]: all children if WHO paediatric stage III.
WHO paediatric stage I (only when CD4 count available) or paediatric stage II:
<18 months: CD4 percentage <20%.
≥18 months: CD4 percentage <15%.
WHO 2006 guidelines [20]: all children if WHO stage 3 or 4 (there are specific rules for WHO stage 3 in case of co-infections).
WHO stage 1 or 2 (total lymphocyte counts are used in sites where CD4 values cannot be determined):
<1 year: CD4 percentage <25% or absolute CD4 cell count <1500 cells/µl.
1 to <3 years: CD4 percentage <20% or absolute CD4 cell count <750 cells/µl.
3 to <5 years: CD4 percentage <15% or absolute CD4 cell count <350 cells/µl.
≥5 years: CD4 percentage <15% or absolute CD4 cell count <200 cells/µl.
• WHO 2010 guidelines [21]: all children if <2 years or in WHO stage 3 or 4.
WHO stage 1 or 2:
2 to <5 years: CD4 percentage ≤25% or absolute CD4 cell count ≤750 cells/µl.
≥5 years: ≤350 cells/µl.
WHO 2003 guidelines [33]: all children if WHO paediatric stage III.
WHO paediatric stage I (only when CD4 count available) or paediatric stage II:
<18 months: CD4 percentage <20%.
≥18 months: CD4 percentage <15%.
WHO 2006 guidelines [20]: all children if WHO stage 3 or 4 (there are specific rules for WHO stage 3 in case of co-infections).
WHO stage 1 or 2 (total lymphocyte counts are used in sites where CD4 values cannot be determined):
<1 year: CD4 percentage <25% or absolute CD4 cell count <1500 cells/µl.
1 to <3 years: CD4 percentage <20% or absolute CD4 cell count <750 cells/µl.
3 to <5 years: CD4 percentage <15% or absolute CD4 cell count <350 cells/µl.
≥5 years: CD4 percentage <15% or absolute CD4 cell count <200 cells/µl.
• WHO 2010 guidelines [21]: all children if <2 years or in WHO stage 3 or 4.
WHO stage 1 or 2:
2 to <5 years: CD4 percentage ≤25% or absolute CD4 cell count ≤750 cells/µl.
≥5 years: ≤350 cells/µl.
**Absolute CD4 count A, percentage CD4 P.
***Of 162 HIV exposed children, all 24 children who were diagnosed HIV positive were included.
%I PLOS ONE