10.1371/journal.pone.0058857.g009
Aseervatham Anusha Amali
Aseervatham
Anusha Amali
Lawrence Sie
Lawrence
Sie
Christoph Winkler
Christoph
Winkler
Mark Featherstone
Mark
Featherstone
Expression of <i>meis1.1,</i> but not <i>cdx4</i>, is impaired in <i>hoxd4a</i> morphants at the shield stage.
Public Library of Science
2013
findings place hoxd 4a
cdx
Hox genes
ventral-most mesoderm fated
hoxd 4a function
group paralog Hoxd 4 display malformations
13 hours post fertilization
meis 1.1 expression
hemangioblast markers scl 1
hoxd 4a acts
PLM
orthologous hoxd 4a gene
Zebrafish hoxd 4a Acts Upstream
meis 1.1
2013-03-16 07:38:40
Figure
https://plos.figshare.com/articles/figure/_Expression_of_meis1_1_but_not_cdx4_is_impaired_in_hoxd4a_morphants_at_the_shield_stage_/653067
<p>Expression of <i>cdx4</i> (A,B), <i>hoxd4a</i> (C–E) and <i>meis1.1</i> (F–H) in control (A,C,F), <i>hoxd4a</i> morphants (B,D,G) and rescuants injected with <i>hoxd4a</i> mRNA (E,H) observed at the shield stage. Asterisks denote the ventral-most mesoderm fated to give rise to hemangioblast in addition to unipotential hematopoietic and angiogenic progenitors. Ratios indicate the fraction of embryos showing the presented phenotype. Scale bars equal 100 µm. (I) qRT-PCR was used to quantitate relative mRNA levels in controls, morphants and rescuants as indicated. Error bars present the standard error. Decreased expression of <i>hoxd4a</i> and <i>meis1.1</i> in <i>hoxd4a</i> morphants is significantly lower than both controls and rescuants to p≤0.02.</p>