10.1371/journal.pone.0058857.g008
Aseervatham Anusha Amali
Aseervatham
Anusha Amali
Lawrence Sie
Lawrence
Sie
Christoph Winkler
Christoph
Winkler
Mark Featherstone
Mark
Featherstone
<i>meis1.1</i> is down regulated in <i>hoxd4a</i> morphants and <i>meis1.1</i> mRNA rescues hematopoietic and vasculogenic gene expression in <i>hoxd4a</i> morphants.
Public Library of Science
2013
findings place hoxd 4a
cdx
Hox genes
ventral-most mesoderm fated
hoxd 4a function
group paralog Hoxd 4 display malformations
13 hours post fertilization
meis 1.1 expression
hemangioblast markers scl 1
hoxd 4a acts
PLM
orthologous hoxd 4a gene
Zebrafish hoxd 4a Acts Upstream
meis 1.1
2013-03-16 07:37:39
Figure
https://plos.figshare.com/articles/figure/_meis1_1_is_down_regulated_in_hoxd4a_morphants_and_meis1_1_mRNA_rescues_hematopoietic_and_vasculogenic_gene_expression_in_hoxd4a_morphants_/653063
<p>Expression of <i>meis1.1</i> in control (A), morphant (B) and <i>hoxd4a</i>-rescuant (C) embryos at 26–28 hpf. (D–I) At 13 hpf, normal expression of <i>gata1</i>, <i>scl1</i> and <i>fli1</i> (D–F) is reduced in <i>hoxd4a</i> morphants (G–I), but rescued upon co-injection with capped mRNA for <i>meis1.1</i> (J–L). (M,N) Rescue of vascular patterning in <i>hoxd4a</i> morphants by co-injection with capped mRNA for <i>meis1.1</i> as visualized in Tg(fli1:EGFP) transgenics at 48 hpf (M) and by alkaline phosphatase staining at 72 hpf (N). Scale bars equal 100 µm.</p>