10.1371/journal.pone.0058857.g006 Aseervatham Anusha Amali Aseervatham Anusha Amali Lawrence Sie Lawrence Sie Christoph Winkler Christoph Winkler Mark Featherstone Mark Featherstone <i>hoxd4a</i> is required for hemangioblast formation. Public Library of Science 2013 findings place hoxd 4a cdx Hox genes ventral-most mesoderm fated hoxd 4a function group paralog Hoxd 4 display malformations 13 hours post fertilization meis 1.1 expression hemangioblast markers scl 1 hoxd 4a acts PLM orthologous hoxd 4a gene Zebrafish hoxd 4a Acts Upstream meis 1.1 2013-03-16 07:35:55 Figure https://plos.figshare.com/articles/figure/_hoxd4a_is_required_for_hemangioblast_formation_/653060 <p>(A,B) Normal expression at 13 hpf of posterior hemangioblast markers <i>scl1</i> (A) and <i>lmo2</i> (B) in the PLM. (C,D) Expression of these markers is greatly reduced in <i>hoxd4a</i> morphants, but is rescued by co-injection of capped mRNA for <i>hoxd4a</i> (E,F). Ratios indicate the fraction of embryos showing the presented phenotype. Anterior is to the left. A, C and E are dorsal views of flat-mounted specimens while B, D and F are lateral views. Scale bars equal 100 µm. A is at a lower magnification than C and E.</p>