An approach to identifying functional groups within the multi-copy <i>var</i> genes.
Mary M. Rorick
Edward B. Baskerville
Thomas S. Rask
Karen P. Day
Mercedes Pascual
10.1371/journal.pcbi.1006174.g002
https://plos.figshare.com/articles/figure/An_approach_to_identifying_functional_groups_within_the_multi-copy_i_var_i_genes_/6512681
<p><b>(A)</b> Graphical representation of a stochastic block model for the normalized co-occurrence matrix <b>Z</b>, for nine homology blocks divided into three functional groups (HB functional groups 1–3). The blocks within the matrix of a single color represent the <i>z</i>-scores between pairs of HB functional groups, which are assumed to be drawn from the same normal distribution. <b>(B)</b> Homology blocks recombine to form <i>var</i> gene sequences, so after homology blocks are classified into functional groups (7 shown here, represented by distinct colors), <i>var</i> functional types can be defined as unique combinations of homology block functional groups (HBFG types). Viewing <i>var</i> sequences as HBFG types reduces diversity by over two orders of magnitude.</p>
2018-06-13 17:54:15
sample var DBL α sequence types
var gene diversity
approach
recombining var antigenic gene family
malaria parasite Plasmodium falciparum
recombining parts
recombining antigenic var genes
multi-copy gene families