10.1371/journal.pcbi.1006174.g002
Mary M. Rorick
Mary M.
Rorick
Edward B. Baskerville
Edward
B. Baskerville
Thomas S. Rask
Thomas
S. Rask
Karen P. Day
Karen
P. Day
Mercedes Pascual
Mercedes
Pascual
An approach to identifying functional groups within the multi-copy <i>var</i> genes.
Public Library of Science
2018
sample var DBL α sequence types
var gene diversity
approach
recombining var antigenic gene family
malaria parasite Plasmodium falciparum
recombining parts
recombining antigenic var genes
multi-copy gene families
2018-06-13 17:54:15
Figure
https://plos.figshare.com/articles/figure/An_approach_to_identifying_functional_groups_within_the_multi-copy_i_var_i_genes_/6512681
<p><b>(A)</b> Graphical representation of a stochastic block model for the normalized co-occurrence matrix <b>Z</b>, for nine homology blocks divided into three functional groups (HB functional groups 1–3). The blocks within the matrix of a single color represent the <i>z</i>-scores between pairs of HB functional groups, which are assumed to be drawn from the same normal distribution. <b>(B)</b> Homology blocks recombine to form <i>var</i> gene sequences, so after homology blocks are classified into functional groups (7 shown here, represented by distinct colors), <i>var</i> functional types can be defined as unique combinations of homology block functional groups (HBFG types). Viewing <i>var</i> sequences as HBFG types reduces diversity by over two orders of magnitude.</p>