10.1371/journal.pone.0058164.g002
David J. Dowling
David
J. Dowling
Zhen Tan
Zhen
Tan
Zofia M. Prokopowicz
Zofia
M. Prokopowicz
Christine D. Palmer
Christine
D. Palmer
Maura-Ann H. Matthews
Maura-Ann
H. Matthews
Gregory N. Dietsch
Gregory
N. Dietsch
Robert M. Hershberg
Robert
M. Hershberg
Ofer Levy
Ofer
Levy
VTX-294 is more potent and effective than R-848 in inducing TNF and IL-1β in whole blood.
Public Library of Science
2013
potent
r-848
inducing
tnf
2013-03-05 09:47:34
Figure
https://plos.figshare.com/articles/figure/_VTX_294_is_more_potent_and_effective_than_R_848_in_inducing_TNF_and_IL_1_946_in_whole_blood_/644128
<p>Human neonatal and adult blood was cultured for 6 h with MPLA (TLR4), R848 (TLR7/8), CL075 (TLR8) and VTX-294 (TLR8) and supernatants collected for TNF or IL-1β ELISA. Compound concentrations are shown in µM, except for MPLA, which are shown in ng/ml. Data are shown as mean ± SEM of n = 5–8. For between-group analyses, Wilcoxon signed-rank test was applied to compare VTX-294 median value to the other compounds at a given concentration. Statistical significance is denoted as follows: *p<0.05 and **p<0.01, with black star(s) for comparison to MPLA, blue star(s) for comparison to R848 and green star(s) for comparison to CL075.</p>