%0 Figure %A Bowater, Richard %A J Doherty, Aidan %D 2013 %T Structure of Eukaryotic, Prokaryotic, and Phage Ku Proteins %U https://plos.figshare.com/articles/figure/_Structure_of_Eukaryotic_Prokaryotic_and_Phage_Ku_Proteins_/629936 %R 10.1371/journal.pgen.0020008.g003 %2 https://plos.figshare.com/ndownloader/files/959913 %K phage %K ku %X

The structure of the human Ku heterodimer bound to DNA [22] is depicted in two different orientations. Ku encircles the end of the DNA like a “nut on a bolt.” The predicted structures of the Ku from Mt and Gam homodimers are also shown. The smaller Ku homologues retain the regions required for dimerization and DNA binding but lack the N-terminal vWA domains, the C-terminal SAP (Ku70), and the DNA-PKcs binding (Ku80) domains present in the larger eukaryotic Ku proteins.

%I PLOS Genetics