10.1371/journal.pone.0195427.g004 Larissa Kägi Larissa Kägi Carla Bettoni Carla Bettoni Eva M. Pastor-Arroyo Eva M. Pastor-Arroyo Udo Schnitzbauer Udo Schnitzbauer Nati Hernando Nati Hernando Carsten A. Wagner Carsten A. Wagner Effect of FGF23 administration on mineral and hormonal levels. Public Library of Science 2018 2 D 3 fibroblast growth factor 23 vitamin D metabolizing enzymes 2 D 3 synthesis OH Pi 2 D 3 Background extrarenal tissues Cyp 24a 25- hydroxylases CYP 2R vitamin D hydroxylases 27A 27B expression 2 D 3 treatment 24- hydroxylase CYP 24A catalyzes vitamin D receptor VDR cytochrome P 450 FGF 23 PTH 2018-05-17 08:17:15 Figure https://plos.figshare.com/articles/figure/Effect_of_FGF23_administration_on_mineral_and_hormonal_levels_/6283661 <p>Urinary and plasma concentrations of Pi <b>(A and B)</b> and Ca<sup>2+</sup> <b>(C and D)</b> as well as plasma levels of PTH <b>(E)</b>, endogenous FGF23 <b>(F)</b>, 1,25(OH)<sub>2</sub>D <b>(G)</b> and recombinant human FGF23 <b>(H)</b> were measured in samples from mice injected with recombinant human FGF23 (rhFGF23) once a day for two consecutive days (black bars) and the respective vehicle treated controls (white bars). Graphs show mean ± SD (n = 5-6/group) and data was analyzed by unpaired student’s t-test with significant p values indicated as: * p ≤ 0.05 and ** p ≤ 0.01.</p>