10.1371/journal.pone.0195427.g004
Larissa Kägi
Larissa
Kägi
Carla Bettoni
Carla
Bettoni
Eva M. Pastor-Arroyo
Eva
M. Pastor-Arroyo
Udo Schnitzbauer
Udo
Schnitzbauer
Nati Hernando
Nati
Hernando
Carsten A. Wagner
Carsten
A. Wagner
Effect of FGF23 administration on mineral and hormonal levels.
Public Library of Science
2018
2 D 3
fibroblast growth factor 23
vitamin D metabolizing enzymes
2 D 3 synthesis
OH
Pi
2 D 3 Background
extrarenal tissues
Cyp 24a
25- hydroxylases CYP 2R
vitamin D hydroxylases
27A
27B
expression
2 D 3 treatment
24- hydroxylase CYP 24A catalyzes
vitamin D receptor VDR
cytochrome P 450
FGF 23
PTH
2018-05-17 08:17:15
Figure
https://plos.figshare.com/articles/figure/Effect_of_FGF23_administration_on_mineral_and_hormonal_levels_/6283661
<p>Urinary and plasma concentrations of Pi <b>(A and B)</b> and Ca<sup>2+</sup> <b>(C and D)</b> as well as plasma levels of PTH <b>(E)</b>, endogenous FGF23 <b>(F)</b>, 1,25(OH)<sub>2</sub>D <b>(G)</b> and recombinant human FGF23 <b>(H)</b> were measured in samples from mice injected with recombinant human FGF23 (rhFGF23) once a day for two consecutive days (black bars) and the respective vehicle treated controls (white bars). Graphs show mean ± SD (n = 5-6/group) and data was analyzed by unpaired student’s t-test with significant p values indicated as: * p ≤ 0.05 and ** p ≤ 0.01.</p>