Brillatz, Théo Lauritano, Chiara Jacmin, Maxime Khamma, Supitcha Marcourt, Laurence Righi, Davide Romano, Giovanna Esposito, Francesco Ianora, Adrianna Queiroz, Emerson F. Wolfender, Jean-Luc Crawford, Alexander D. ELSD chromatograms for the methanolic extract before and after enrichment, and its fractionation by preparative chromatography. <p>(A) UHPLC chromatogram of the crude methanolic extract exhibiting mainly unretained polar metabolites. (B) UHPLC metabolite profiling after enrichment by VLC to remove very polar residues. (C) Preparative chromatography for the fractionation of the enriched extract highlighting the isolation of constituent <b>1</b>.</p> bioassay-guided fractionation;diatom Skeletonema marinoi;marine diatom Skeletonema marinoi;anticonvulsant activity;UHPLC-HRMS;adenosine receptor agonist;microalgae;neuroactive;antiseizure nucleoside inosine;vivo zebrafish bioassay;constituent;zebrafish epilepsy model;metabolite;rat epilepsy models;GABA 2018-04-24
    https://plos.figshare.com/articles/figure/ELSD_chromatograms_for_the_methanolic_extract_before_and_after_enrichment_and_its_fractionation_by_preparative_chromatography_/6178784
10.1371/journal.pone.0196195.g002