10.1371/journal.pone.0196195.g002
Théo Brillatz
Théo
Brillatz
Chiara Lauritano
Chiara
Lauritano
Maxime Jacmin
Maxime
Jacmin
Supitcha Khamma
Supitcha
Khamma
Laurence Marcourt
Laurence
Marcourt
Davide Righi
Davide
Righi
Giovanna Romano
Giovanna
Romano
Francesco Esposito
Francesco
Esposito
Adrianna Ianora
Adrianna
Ianora
Emerson F. Queiroz
Emerson F.
Queiroz
Jean-Luc Wolfender
Jean-Luc
Wolfender
Alexander D. Crawford
Alexander D.
Crawford
ELSD chromatograms for the methanolic extract before and after enrichment, and its fractionation by preparative chromatography.
Public Library of Science
2018
bioassay-guided fractionation
diatom Skeletonema marinoi
marine diatom Skeletonema marinoi
anticonvulsant activity
UHPLC-HRMS
adenosine receptor agonist
microalgae
neuroactive
antiseizure nucleoside inosine
vivo zebrafish bioassay
constituent
zebrafish epilepsy model
metabolite
rat epilepsy models
GABA
2018-04-24 17:41:03
Figure
https://plos.figshare.com/articles/figure/ELSD_chromatograms_for_the_methanolic_extract_before_and_after_enrichment_and_its_fractionation_by_preparative_chromatography_/6178784
<p>(A) UHPLC chromatogram of the crude methanolic extract exhibiting mainly unretained polar metabolites. (B) UHPLC metabolite profiling after enrichment by VLC to remove very polar residues. (C) Preparative chromatography for the fractionation of the enriched extract highlighting the isolation of constituent <b>1</b>.</p>