Reservoir approach schematics and validation.
Michael Pablo
Samuel A. Ramirez
Timothy C. Elston
10.1371/journal.pcbi.1006016.g007
https://plos.figshare.com/articles/figure/Reservoir_approach_schematics_and_validation_/5973190
<p><b>(A)</b> Molecules can diffuse in and out of the reservoir. Although distinct molecules are shown for illustration, the reservoir is perfectly mixed. <b>(B)</b> Particles at a depth <i>z</i> must diffuse a distance of either <i>z</i><sub><i>impl</i></sub>—<i>z</i> to enter, or <i>z</i>–<i>z</i><sub><i>impl</i></sub> to exit, the explicit simulation domain. The integrals are solved numerically over discrete slices with thickness Δz. <b>(C)</b> Time courses of the number of molecules in the explicit domain, comparing our approach and a non-reactive Brownian dynamics simulation. The shaded regions represent the mean±1 S.D. over 5 realizations. <b>(D)</b> Time-averaged comparisons, mean±1 S.D. of fluctuations, over 500s, 1 realization.</p>
2018-03-12 17:26:59
polarity establishment
membrane
fluctuations speed polarity establishment
macroscopic rate constants
reaction-diffusion equation simulations
Turing pattern formation Polarity establishment
Cdc 42 abundances
particle-based simulations
yeast polarity establishment
yeast polarization
molecule
Rho GTPase Cdc 42
model