%0 Figure %A Milani, Diego %A Bakeberg, Megan C. %A Cross, Jane L. %A Clark, Vince W. %A Anderton, Ryan S. %A Blacker, David J. %A Knuckey, Neville W. %A Meloni, Bruno P. %D 2018 %T Infarct volume analysis, cerebral hemisphere swelling and representative images of coronal brain slices as assessed 24-hours after permanent MCAO. %U https://plos.figshare.com/articles/figure/Infarct_volume_analysis_cerebral_hemisphere_swelling_and_representative_images_of_coronal_brain_slices_as_assessed_24-hours_after_permanent_MCAO_/5959138 %R 10.1371/journal.pone.0193884.g001 %2 https://plos.figshare.com/ndownloader/files/10679290 %K D-enantiomer R 18D %K neuroprotective efficacy %K Sprague Dawley rat %K bEND .3 cells %K neuroprotective properties %K Wistar rat %K poly-arginine peptide R 18 %K artery occlusion %K R 18D %K 24- hour exposure %K R 18 %K novel neuroprotective agent %K infarct volume %K poly-arginine R 18 %K MCAO %K HEK %K R 18 peptide %K poly-arginine peptides %K 24- hour peptide exposure duration %K 0.058 vs 3 %X

Treatments were administered intravenously (saline vehicle, or R18 and R18D at 300 nmol/kg) 30 min after MCAO. A: Infarct volume measurements. Denotes animal that died several hours before the 24-hour post-MCAO study end-point, but was still included in the final infarct volume analysis. Unfilled circles, triangles and squares represent infarct volumes obtained from outlier animals excluded from the study. B: Percentage hemisphere swelling for vehicle and the R18 and R18D treatment groups. C: Representative images of TTC stained coronal brain slices from vehicle, R18 and R18D treatment groups. Values are mean ± SD; n = 9–10. *p < 0.05 when compared to vehicle.

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