Just, Stefan Chenard, Bertrand L. Ceci, Angelo Strassmaier, Timothy A. Chong, Jayhong Blair, Nathaniel T. Gallaschun, Randall J. del Camino, Donato Cantin, Susan D’Amours, Marc Eickmeier, Christian M. Fanger, Christopher Hecker, Carsten Hessler, David P. Hengerer, Bastian Kroker, Katja S. Malekiani, Sam Mihalek, Robert McLaughlin, Joseph Rast, Georg Witek, JoAnn Sauer, Achim Pryce, Christopher R. M. Moran, Magdalene Structures and activity in fluorometric assays of HC-070 and HC-608. <p>The chemical structures of (A) HC-070 and (B) HC-608 (Pico145). (C) Inhibition of hTRPC5 by HC-070 and HC-608 in indicator-assisted calcium influx analysis. Concentrations tested ranged from 1 picomolar (pM) to 1 μM. Each data point represents the average of 8 measurements from a 384-well plate. Error bars show the standard deviation. The IC<sub>50</sub> values were 9.3 ± 0.9 and 6.2 ± 0.5 nanomolar (nM), respectively. (D) Inhibition of hTRPC4 by HC-070 and HC-608 over the same range of concentrations. The IC<sub>50</sub> values were 46.0 ± 3.9 nM and 32.5 ± 1.8 nM, respectively (n = 8). Error bars represent the standard deviation.</p> HC -070. HC -070;EPM;CCK;TRPC 5 channels;non-selective cation channels;heterologous expression systems;HC -070;TRPC 5;TRPC 4;HC -070 ameliorates;molecule antagonist;HC -070 attenuates;TRPC 5 homomultimers;channel canonical subfamily;IC;TRPC 5 mice 2018-01-31
    https://plos.figshare.com/articles/figure/Structures_and_activity_in_fluorometric_assays_of_HC-070_and_HC-608_/5843088
10.1371/journal.pone.0191225.g001