Comparison of maximum and minimum number of memory T cells formed in PB vaccines using different total antigen doses.
Cristina Fernandez-Arias
Clemente F. Arias
Min Zhang
Miguel A. Herrero
Francisco J. Acosta
Moriya Tsuji
10.1371/journal.pone.0190940.g005
https://plos.figshare.com/articles/figure/Comparison_of_maximum_and_minimum_number_of_memory_T_cells_formed_in_PB_vaccines_using_different_total_antigen_doses_/5784693
<p>Performance of PB protocols defined as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190940#pone.0190940.g004" target="_blank">Fig 4</a> for low, intermediate and high vaccine doses (the rest of parameter values are randomly chosen as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190940#pone.0190940.g004" target="_blank">Fig 4</a>). A) Each dot represents the maximum number of memory T cells for PB protocols with low and intermediate antigen doses. All the dots are above the line of equation <i>x</i> = <i>y</i> (dashed line), which implies that it is possible to produce more memory T cells with intermediate than with low antigen doses. B) Same as in A for intermediate vs high antigen doses. C,D) The maximum number of memory T cells produced with lower antigen doses can be larger than the minimum of memory T cells created when higher antigen doses are used.</p>
2018-01-12 09:09:35
vaccine doses
pre-erythrocytic stages
clonal contraction
T cell memory production
sporozoite prime-boost vaccines Vaccination
T cell response
T cell dynamics
Experimental data
timing
prime-boost vaccines
Empirical evidence
radiation-attenuated sporozoites
model
inoculation