10.1371/journal.pone.0190940.g005
Cristina Fernandez-Arias
Cristina
Fernandez-Arias
Clemente F. Arias
Clemente F.
Arias
Min Zhang
Min
Zhang
Miguel A. Herrero
Miguel
A. Herrero
Francisco J. Acosta
Francisco J.
Acosta
Moriya Tsuji
Moriya
Tsuji
Comparison of maximum and minimum number of memory T cells formed in PB vaccines using different total antigen doses.
Public Library of Science
2018
vaccine doses
pre-erythrocytic stages
clonal contraction
T cell memory production
sporozoite prime-boost vaccines Vaccination
T cell response
T cell dynamics
Experimental data
timing
prime-boost vaccines
Empirical evidence
radiation-attenuated sporozoites
model
inoculation
2018-01-12 09:09:35
Figure
https://plos.figshare.com/articles/figure/Comparison_of_maximum_and_minimum_number_of_memory_T_cells_formed_in_PB_vaccines_using_different_total_antigen_doses_/5784693
<p>Performance of PB protocols defined as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190940#pone.0190940.g004" target="_blank">Fig 4</a> for low, intermediate and high vaccine doses (the rest of parameter values are randomly chosen as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190940#pone.0190940.g004" target="_blank">Fig 4</a>). A) Each dot represents the maximum number of memory T cells for PB protocols with low and intermediate antigen doses. All the dots are above the line of equation <i>x</i> = <i>y</i> (dashed line), which implies that it is possible to produce more memory T cells with intermediate than with low antigen doses. B) Same as in A for intermediate vs high antigen doses. C,D) The maximum number of memory T cells produced with lower antigen doses can be larger than the minimum of memory T cells created when higher antigen doses are used.</p>