10.1371/journal.pone.0190940.g005 Cristina Fernandez-Arias Cristina Fernandez-Arias Clemente F. Arias Clemente F. Arias Min Zhang Min Zhang Miguel A. Herrero Miguel A. Herrero Francisco J. Acosta Francisco J. Acosta Moriya Tsuji Moriya Tsuji Comparison of maximum and minimum number of memory T cells formed in PB vaccines using different total antigen doses. Public Library of Science 2018 vaccine doses pre-erythrocytic stages clonal contraction T cell memory production sporozoite prime-boost vaccines Vaccination T cell response T cell dynamics Experimental data timing prime-boost vaccines Empirical evidence radiation-attenuated sporozoites model inoculation 2018-01-12 09:09:35 Figure https://plos.figshare.com/articles/figure/Comparison_of_maximum_and_minimum_number_of_memory_T_cells_formed_in_PB_vaccines_using_different_total_antigen_doses_/5784693 <p>Performance of PB protocols defined as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190940#pone.0190940.g004" target="_blank">Fig 4</a> for low, intermediate and high vaccine doses (the rest of parameter values are randomly chosen as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190940#pone.0190940.g004" target="_blank">Fig 4</a>). A) Each dot represents the maximum number of memory T cells for PB protocols with low and intermediate antigen doses. All the dots are above the line of equation <i>x</i> = <i>y</i> (dashed line), which implies that it is possible to produce more memory T cells with intermediate than with low antigen doses. B) Same as in A for intermediate vs high antigen doses. C,D) The maximum number of memory T cells produced with lower antigen doses can be larger than the minimum of memory T cells created when higher antigen doses are used.</p>