%0 Figure %A R. Eyring, Kenneth %A S. Pedersen, Brent %A Maclean, Kenneth N. %A Stabler, Sally P. %A Yang, Ivana V. %A Schwartz, David A. %D 2018 %T Single carbon metabolite levels differ between C57BL/6Mthfr-/- and C57BL/6 mice. %U https://plos.figshare.com/articles/figure/Single_carbon_metabolite_levels_differ_between_C57BL_6_sup_i_Mthfr_i_-_-_sup_and_C57BL_6_mice_/5784666 %R 10.1371/journal.pone.0190916.g001 %2 https://plos.figshare.com/ndownloader/files/10211469 %K airway disease %K WLL %K Methods Allergic airway disease %K Mthfr %K AHR %K HDM-treated C 57BL mice %K lung tissue %K C 57BL %K airway disease phenotype %K methyl donors %K house dust mite %K airway disease Rationale Environmental exposures %K carbon metabolite levels %X

(A) Single Carbon metabolism pathway. C57BL/6Mthfr-/- mice demonstrate altered levels of single carbon metabolites (homocysteine, HCYS; cystathionine, CYSTAT; dimethylglycine, DMG; methylglycine, MG; methionine, METH; cysteine, CYS; glycine, GLY; alpha aminobutyrate, ABUT; serine, SER) in (B) serum and (C) whole lung tissue compared to C57BL/6 mice (C57BL/6 black bars; C57Bl/6Mthfr-/- white bars, * p-value <0.05, *** p-value <0.001).

%I PLOS ONE