10.1371/journal.pone.0190333.g003
Miki Shimbo
Miki
Shimbo
Riku Suzuki
Riku
Suzuki
Sayaka Fuseya
Sayaka
Fuseya
Takashi Sato
Takashi
Sato
Katsue Kiyohara
Katsue
Kiyohara
Kozue Hagiwara
Kozue
Hagiwara
Risa Okada
Risa
Okada
Hiromasa Wakui
Hiromasa
Wakui
Yuki Tsunakawa
Yuki
Tsunakawa
Hideto Watanabe
Hideto
Watanabe
Koji Kimata
Koji
Kimata
Hisashi Narimatsu
Hisashi
Narimatsu
Takashi Kudo
Takashi
Kudo
Satoru Takahashi
Satoru
Takahashi
Phenotype of Col2-DKO mice.
Public Library of Science
2017
WT
Quantitative RT-PCR analysis
t 2
t 1
CS synthesis
cartilage-specific t 1
t 1 KO mice
Col 2a 1
chondrocyte
endochondral ossification
ECM
CS content
Ptch 1 transcripts
t 2 KO mice
chondroitin sulfate N
GAG expression levels
t 1 KO cartilage
-2 Chondroitin sulfate
Col 2-DKO mice
DKO cartilage
t 1 KO
E 18.5 cartilage
Col 2-DKO knee cartilage
2017-12-29 18:34:03
Figure
https://plos.figshare.com/articles/figure/Phenotype_of_Col2-DKO_mice_/5744877
<p>(A) Representative photograph of Control pups and Col2-DKO littermates at E18.5, P7, and P14. Scale bar: 1 cm. (B) Body weight of Control (E18.5; n = 16, P7; n = 4, P14; n = 4) and Col2-DKO (E18.5; n = 12, P7; n = 4, P14; n = 4) mice at various stages. *<i>P</i> < 0.05, **<i>P</i> < 0.01. (C) Humeral and tibial bone length at E18.5 of Control (n = 6) and Col2-DKO (n = 7) mice. (D) Quantitative analysis of <i>t1</i> and <i>t2</i> transcripts in the knee cartilage of WT (n = 3) and Col2-DKO (n = 3) mice at E18.5 using real-time RT-PCR. The expression of each transcript was normalized to that of β-actin. **<i>P</i> < 0.01.</p>