10.1371/journal.pone.0005836.g007 Wesley A. Beckstead Wesley A. Beckstead Mark T. W. Ebbert Mark T. W. Ebbert Mark J. Rowe Mark J. Rowe David A. McClellan David A. McClellan The water channel that leads up into the hydrophobic membrane region where the Q<sub>i</sub> binding site is embedded. Public Library of Science 2009 leads hydrophobic membrane binding 2009-06-08 01:53:33 Figure https://plos.figshare.com/articles/figure/_The_water_channel_that_leads_up_into_the_hydrophobic_membrane_region_where_the_Q_i_binding_site_is_embedded_/566813 <p>The approximate location of the membrane was obtained from Gao et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005836#pone.0005836-Gao1" target="_blank">[35]</a>. The electrostatic surface is shown for the residues of complex III (only one monomer shown). Cytb is colored in grey and the surrounding subunits are shown in green. The CoQ coenzymes (pink and purple) are shown bound in their respective sites. The N-terminus tail of cytb has been highlighted according to the hydropathy of the residues in order to show the potential path for water to be shuttled up into the Q<sub>i</sub> site. Hydrophilic residues on the cytb tail are highlighted in orange and hydrophobic residues are highlighted in red. The figure shows a potential hydrophilic channel up the cytb tail that allows water into hydrophobic membrane and into the Q<sub>i</sub> site. The cytbI7T polymorphism (yellow) resides in the center of this water channel.</p>