Rudobeck, Emil Bellone, John A. Szücs, Attila Bonnick, Kristine Mehrotra-Carter, Shalini Badaut, Jerome Nelson, Gregory A. E. Hartman, Richard Vlkolinský, Roman IHC analyses of Aβ deposits in TG mice 9 months post-irradiation. <p>Top left panel: A representative illustration of a medial coronal section of the brain of a TG mouse divided into 3 areas of interest: hippocampus (HPC, dorsal cortex (DC) and ventral cortex (VC). The purple spots indicate the software’s built-in algorithm detection of amyloid plaques that was further visually confirmed by the experimenter. Top right panel: Original micrographs of cortical sections exposed to 0–1 Gy. Bottom panels: Relative numbers of plaque areas measured in the hippocampus and the dorsal cortex. Significant differences in Aβ deposition were detected between 0 vs 1 Gy groups in the DC and similar trends were observed in the HPC. TG mice only: N = 8, 7, 4 and 5 animals/radiation group. Statistical analyses: 1-way ANOVA, Post hoc * <i>p</i><0.05. Data represent means ± SEM.</p> CCL;9 months post-irradiation;WT mice;WM;Low-dose proton radiation effects;space travel Space radiation;Ground-based animal studies;APP;synaptic transmission;TG mice;presynaptic marker synaptophysin;CXCL;bead-based multiplex assay;space radiation spectrum;β deposition;6 months post-irradiation;CA 1 neurons;AD;TNF;IL;pro-inflammatory cytokine levels 2017-11-29
    https://plos.figshare.com/articles/figure/IHC_analyses_of_A_deposits_in_TG_mice_9_months_post-irradiation_/5645950
10.1371/journal.pone.0186168.g007