%0 Figure %A Rudobeck, Emil %A Bellone, John A. %A Szücs, Attila %A Bonnick, Kristine %A Mehrotra-Carter, Shalini %A Badaut, Jerome %A Nelson, Gregory A. %A E. Hartman, Richard %A Vlkolinský, Roman %D 2017 %T IHC analyses of Aβ deposits in TG mice 9 months post-irradiation. %U https://plos.figshare.com/articles/figure/IHC_analyses_of_A_deposits_in_TG_mice_9_months_post-irradiation_/5645950 %R 10.1371/journal.pone.0186168.g007 %2 https://plos.figshare.com/ndownloader/files/9848107 %K CCL %K 9 months post-irradiation %K WT mice %K WM %K Low-dose proton radiation effects %K space travel Space radiation %K Ground-based animal studies %K APP %K synaptic transmission %K TG mice %K presynaptic marker synaptophysin %K CXCL %K bead-based multiplex assay %K space radiation spectrum %K β deposition %K 6 months post-irradiation %K CA 1 neurons %K AD %K TNF %K IL %K pro-inflammatory cytokine levels %X

Top left panel: A representative illustration of a medial coronal section of the brain of a TG mouse divided into 3 areas of interest: hippocampus (HPC, dorsal cortex (DC) and ventral cortex (VC). The purple spots indicate the software’s built-in algorithm detection of amyloid plaques that was further visually confirmed by the experimenter. Top right panel: Original micrographs of cortical sections exposed to 0–1 Gy. Bottom panels: Relative numbers of plaque areas measured in the hippocampus and the dorsal cortex. Significant differences in Aβ deposition were detected between 0 vs 1 Gy groups in the DC and similar trends were observed in the HPC. TG mice only: N = 8, 7, 4 and 5 animals/radiation group. Statistical analyses: 1-way ANOVA, Post hoc * p<0.05. Data represent means ± SEM.

%I PLOS ONE