10.1371/journal.pone.0188239.g003
David Reyes-Corona
David
Reyes-Corona
Nallely Vázquez-Hernández
Nallely
Vázquez-Hernández
Lourdes Escobedo
Lourdes
Escobedo
Carlos E. Orozco-Barrios
Carlos E.
Orozco-Barrios
Jose Ayala-Davila
Jose
Ayala-Davila
Mario Gil Moreno
Mario Gil
Moreno
Miriam E. Amaro-Lara
Miriam E.
Amaro-Lara
Yazmin M. Flores-Martinez
Yazmin M.
Flores-Martinez
Armando J. Espadas-Alvarez
Armando
J. Espadas-Alvarez
Manuel A. Fernandez-Parrilla
Manuel A.
Fernandez-Parrilla
Juan A. Gonzalez-Barrios
Juan A.
Gonzalez-Barrios
ME Gutierrez-Castillo
ME
Gutierrez-Castillo
Ignacio González-Burgos
Ignacio
González-Burgos
Daniel Martinez-Fong
Daniel
Martinez-Fong
NRTN gene transfection increases TH(+) fibers in the striatum of rats with chronic 6-OHDA lesion.
Public Library of Science
2017
postsynaptic
NRTN causes presynaptic
neurotrophic
nigrostriatal dopaminergic system
NTS-polyplex nanoparticles system
Neurotensin receptor type 1 levels
6- hydroxydopamine lesion
dopaminergic neurons
striatum
OHDA
neurite
striatal dendritic spines
substantia nigra
striatal medium spiny neurons
recovery
TH
overexpression
2017-11-27 18:31:25
Figure
https://plos.figshare.com/articles/figure/NRTN_gene_transfection_increases_TH_fibers_in_the_striatum_of_rats_with_chronic_6-OHDA_lesion_/5635864
<p><b>A.</b> Representative micrographs of TH immunohistochemistry. Headings = Anterior-posterior coordinates of Paxinos and Watson Rat Atlas [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0188239#pone.0188239.ref054" target="_blank">54</a>]. 24WLUT = Untransfected rats with 24 weeks of 6-OHDA lesion. 12WL4WT = 12 weeks after lesion and 4 weeks after transfection, 12WL12WT = 12 weeks after lesion and 12 weeks after transfection. The scale bar of 1 mm is for slices at different levels and of 100 μm for details. <b>B.</b> Densitometry of TH(+) relative area. 4WT and 12 WT = 4 and 12 weeks after transfection. 24WL = untransfected rats with 24 weeks of lesion. 12WL = 12 weeks after lesion. The transfections of pGreenLantern-1 (GFP) and pTracer-mNRTN-His (NRTN) plasmids were made at week 12 after lesion. One-way ANOVA and Newman-Keuls post-test. * <i>P</i> < 0.001, ** <i>P</i> < 0.0001. ns = no statistical significance, <i>P</i> > 0.05.</p>