Mapping of rare variants to diacylglycerol lipase alpha. Douglas R. Smith Christine M. Stanley Theodore Foss Richard G. Boles Kevin McKernan 10.1371/journal.pone.0187926.g002 https://plos.figshare.com/articles/figure/Mapping_of_rare_variants_to_diacylglycerol_lipase_alpha_/5610520 <p>The location of rare coding variants relative to domains of the enzyme and regulatory phosphorylation sites are indicated, based on NCBI Reference Sequence: NP_006124.1. Red dot: rare variant; purple dots: two variants present in one subject; T (light green shading): transmembrane domain; light blue shading: lipase domain; A (purple shading): Active site; N (magenta shading): Nucleophilic elbow; blue vertical lines: phosphorylation sites.</p> 2017-11-16 18:57:23 2- AG synthesis type 1 cannabinoid receptor orthologous gene knockouts CNR 1 variants endocannabinoid system genes CNR 1 CNR 2 endocannabinoid 2- AG DAGLA encodes diacylglycerol lipase FAAH MGLL CB 1 receptors phenotype core endocannabinoid system genes CNR 1 3 D structure endocannabinoid deficiency syndrome