Mapping of rare variants to diacylglycerol lipase alpha.
Douglas R. Smith
Christine M. Stanley
Theodore Foss
Richard G. Boles
Kevin McKernan
10.1371/journal.pone.0187926.g002
https://plos.figshare.com/articles/figure/Mapping_of_rare_variants_to_diacylglycerol_lipase_alpha_/5610520
<p>The location of rare coding variants relative to domains of the enzyme and regulatory phosphorylation sites are indicated, based on NCBI Reference Sequence: NP_006124.1. Red dot: rare variant; purple dots: two variants present in one subject; T (light green shading): transmembrane domain; light blue shading: lipase domain; A (purple shading): Active site; N (magenta shading): Nucleophilic elbow; blue vertical lines: phosphorylation sites.</p>
2017-11-16 18:57:23
2- AG synthesis
type 1 cannabinoid receptor
orthologous gene knockouts
CNR 1 variants
endocannabinoid system genes CNR 1
CNR 2
endocannabinoid 2- AG
DAGLA
encodes diacylglycerol lipase
FAAH
MGLL
CB 1 receptors
phenotype
core endocannabinoid system genes CNR 1
3 D structure
endocannabinoid deficiency syndrome