Hwang, In-Hu Oh, Seung Yoon Jang, Hyun-Jin Jo, Eunbi Joo, Jong Cheon Lee, Kyung-Bok Yoo, Hwa-Seung Lee, Mi Young Jung Park, Soo Jang, Ik-Soon Cordycepin mediates the regulation of MKK7 by GADD45B via NF-κB suppression. <p>(A) Effect of GADD45B on MKK7 expression in cordycepin-treated TK-10 cells. (B) Effect of MKK7 on JNK expression in cordycepin-treated TK-10 cells. (C) Effect of TNF-α-induced NF-κB on c-FLIP<sub>L</sub> expression. (D) Effect of c-FLIP<sub>L</sub> on JNK expression in cordycepin-treated TK-10 cells. The data represent the mean ± SE from three independent experiments. **<i>p</i> < 0.01 and *** <i>p</i> < 0.001.</p> c-FLIP L inhibition;NF -κB c-FLIP L;c-FLIP L overexpression;c-FLIP L;MKK 7-JNK;c-FLIP L expression Cellular FLICE;TK -10 cell apoptosis;Cordycepin downregulated GADD 45B;cancer cell apoptosis;cordycepin-mediated JNK activation;JNK inhibitor SP 600125;cordycepin-treated TK -10 cells;upregulated MKK 7;siRNA-mediated knockdown;NF -κB;c-FLIP L expression;TNF;TK -10 cells 2017-10-18
    https://plos.figshare.com/articles/figure/Cordycepin_mediates_the_regulation_of_MKK7_by_GADD45B_via_NF-_B_suppression_/5512282
10.1371/journal.pone.0186489.g005