Effect of retinal detachment on electrophysiological properties of Müller cells. Abdoulaye Sene Ramin Tadayoni Thomas Pannicke Antje Wurm Brahim El Mathari Romain Benard Michel Joseph Roux David Yaffe Dominique Mornet Andreas Reichenbach Jose-Alain Sahel Alvaro Rendon 10.1371/journal.pone.0007329.g004 https://plos.figshare.com/articles/figure/_Effect_of_retinal_detachment_on_electrophysiological_properties_of_M_252_ller_cells_/551228 <p>The cells were isolated from control and detached retina of wt and Dp71-null mice and were investigated 7 days after surgery. A: Examples of membrane currents evoked by depolarizing and hyperpolarizing voltage steps from a holding potential of −80 mV to potentials between −180 and +20 mV. No strong alterations of current kinetics were observed. B: Inward current amplitudes recorded at a −60 mV hyperpolarizing step. A weakly significant decrease was observed in cells from wt mice. C: Membrane capacitances were increased after retinal detachment in Müller cells from wt and Dp71-null mice. D: Resulting from decreased currents and increased capacitances, inward current densities were significantly reduced. Current densities were calculated from the data shown in B and C. Each bar represents mean values with standard deviations of 12 cells from 3 mice. Significant differences after retinal detachment versus the respective untreated control: * p<0.05, ** p<0.01, *** p<0.001.</p> 2009-10-07 00:20:28 retinal detachment electrophysiological properties