Effect of retinal detachment on electrophysiological properties of Müller cells.
Abdoulaye Sene
Ramin Tadayoni
Thomas Pannicke
Antje Wurm
Brahim El Mathari
Romain Benard
Michel Joseph Roux
David Yaffe
Dominique Mornet
Andreas Reichenbach
Jose-Alain Sahel
Alvaro Rendon
10.1371/journal.pone.0007329.g004
https://plos.figshare.com/articles/figure/_Effect_of_retinal_detachment_on_electrophysiological_properties_of_M_252_ller_cells_/551228
<p>The cells were isolated from control and detached retina of wt and Dp71-null mice and were investigated 7 days after surgery. A: Examples of membrane currents evoked by depolarizing and hyperpolarizing voltage steps from a holding potential of −80 mV to potentials between −180 and +20 mV. No strong alterations of current kinetics were observed. B: Inward current amplitudes recorded at a −60 mV hyperpolarizing step. A weakly significant decrease was observed in cells from wt mice. C: Membrane capacitances were increased after retinal detachment in Müller cells from wt and Dp71-null mice. D: Resulting from decreased currents and increased capacitances, inward current densities were significantly reduced. Current densities were calculated from the data shown in B and C. Each bar represents mean values with standard deviations of 12 cells from 3 mice. Significant differences after retinal detachment versus the respective untreated control: * p<0.05, ** p<0.01, *** p<0.001.</p>
2009-10-07 00:20:28
retinal
detachment
electrophysiological
properties