Raoufi-Rad, Newsha McRobb, Lucinda S. Lee, Vivienne S. Bervini, David Grace, Michael Ukath, Jaysree Mchattan, Joshua K. A. Sreenivasan, Varun Duong, T. T. Hong Zhao, Zhenjun Stoodley, Marcus A. <i>In vivo</i> near-infrared fluorescence imaging of Xenolight 750 probes in the rat AVM model. <p>Rats with an AVM creation were sham treated or irradiated with a 15 Gy marginal dose to the AVM region by Gamma Knife and imaging performed 12 h after conjugate dye injection (25 μg/kg). Representative montages of x-ray (left), fluorescent (centre) and merged (right) images after injection of Xenolight 750 probes: (A) Xenolight-750 isotype control in irradiated animal; (B) Xenolight 750-ICAM-1 probe and; (C) Xenolight 750-VCAM-1 probe, at day 21 after sham (top panels) or radiation (bottom panels). Image J quantitation of fluorescence at day 21 post-irradiation or sham with Xenolight 750-ICAM-1 (D) or Xenolight 750-VCAM-1 (E) probes and Xenolight-750 isotype control probe.</p> AVM vessels;arteriovenous malformation Focussed radiosurgery;NIR;intercellular adhesion molecule 1;adhesion molecule expression;25 Gy;15 Gy dose;cell adhesion molecule 1;Gamma Knife surgery;ELISA;vivo;VCAM;rat AVM model;Cultured brain microvascular EC;ICAM;cell adhesion molecule expression 2017-09-26
    https://plos.figshare.com/articles/figure/_i_In_vivo_i_near-infrared_fluorescence_imaging_of_Xenolight_750_probes_in_the_rat_AVM_model_/5444824
10.1371/journal.pone.0185393.g004