Estimates of the average turnover rates of human T cells. V. GanusovVitaly A. M. BorghansJosé De BoerRob J. 2010 <p>Data on deuterium labeling of CD4<sup>+</sup> (panel A) and CD8<sup>+</sup> (panel B) T cells in four healthy humans were fitted with three different models: the Asymptote model (empty bars), the Exponential model (gray bars), in which a fraction of the cells have exponentially-distributed turnover rates, and the Gamma model (black bars) with gamma-distributed turnover rates. Best fits of the data are shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000666#pcbi-1000666-g006" target="_blank">Figure 6</a>, and estimates of all parameters of the models are shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000666#pcbi.1000666.s002" target="_blank">Table S2</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000666#pcbi.1000666.s003" target="_blank">S3</a>. Confidence intervals were obtained by bootstrapping the residuals with 1000 simulations. Note that all models deliver very similar estimates for the average turnover rate , with the exception of the estimated CD8<sup>+</sup> T-cell turnover rates in individual c1 which are highly model-dependent.</p>