Pathological changes (a,c) and immunohistochemical detection of viral antigen.
Sharon M. Brookes
Alejandro Núñez
Bhudipa Choudhury
Mikhail Matrosovich
Stephen C. Essen
Derek Clifford
Marek J. Slomka
Gaëlle Kuntz-Simon
Fanny Garcon
Bethany Nash
Amanda Hanna
Peter M. H. Heegaard
Stéphane Quéguiner
Chiara Chiapponi
Michel Bublot
Jaime Maldonado Garcia
Rebecca Gardner
Emanuela Foni
Willie Loeffen
Lars Larsen
Kristien Van Reeth
Jill Banks
Richard M. Irvine
Ian H. Brown
10.1371/journal.pone.0009068.g002
https://plos.figshare.com/articles/figure/_Pathological_changes_a_c_and_immunohistochemical_detection_of_viral_antigen_/534911
<p><b>a</b>. Lung. In-contact animal (TC4), 11 dpc. Multiple dark red areas of cranioventral pulmonary consolidation in the cranial and middle lung lobes. <b>b</b>. Nasal mucosa, 2 dpi. Influenza A nucleoprotein (brown) in numerous respiratory epithelial cells 20x. <b>c</b>. Lung, 7 dpi. Marked attenuation of bronchiolar epithelium due to epithelial cell necrosis, bronchiolar plug and peribronchiolar lymphohistiocytic infiltration. Haematoxylin and eosin 40x. <b>d</b>. Lung, 4 dpi. Viral nucleoprotein in abundant bronchiolar epithelial cells and cellular debris in the bronchiolar lumen and in several pulmonary alveolar macrophages 20x.</p>
2010-02-05 01:21:51
changes
immunohistochemical
detection
viral