%0 Figure %A Akladios, Bassem %A Reinoso, Veronica Mendoza %A E. Cain, Jason %A Wang, Taopeng %A Lambie, Duncan L. %A Neil Watkins, D. %A Beverdam, Annemiek %D 2017 %T A model outlining the cross-regulatory interactions between epidermal YAP, ROCK, β-catenin and Hh signalling. %U https://plos.figshare.com/articles/figure/A_model_outlining_the_cross-regulatory_interactions_between_epidermal_YAP_ROCK_-catenin_and_Hh_signalling_/5325781 %R 10.1371/journal.pone.0183178.g006 %2 https://plos.figshare.com/ndownloader/files/9139981 %K epidermal YAP activity drives GLI 2 %K basal cell carcinoma %K ECM %K postnatal tissue homeostasis %K YAP 2-5SA mice %K control tissue homeostasis %K Hedgehog %K GLI 2 activity %K epidermal β- catenin activation %K BCC development %K mouse skin %X

(A) Epidermal SmoM2 activates YAP, ROCK signalling and dermal fibroblasts in the dorsal skin of K14-CreER/Rosa-SmoM2 transgenic mice (based on Figs 1 and 2). (B) Epidermal YAP activates GLI2 mediated by β-catenin activation in the dorsal skin of YAP2-5SA-ΔC transgenic mice (based on Figs 3 and 4). (C) A model outlining the proposed regulatory interactions between epidermal YAP, Hedgehog and ROCK-dependent mechanosignalling to balance skin regeneration based on our findings (red arrows) and on cited studies [25, 27, 29, 34, 39, 40, 45, 47, 48, 63, 64, 65, 66, 69].

%I PLOS ONE