10.1371/journal.pone.0183178.g006
Bassem Akladios
Bassem
Akladios
Veronica Mendoza Reinoso
Veronica Mendoza
Reinoso
Jason E. Cain
Jason
E. Cain
Taopeng Wang
Taopeng
Wang
Duncan L. Lambie
Duncan L.
Lambie
D. Neil Watkins
D.
Neil Watkins
Annemiek Beverdam
Annemiek
Beverdam
A model outlining the cross-regulatory interactions between epidermal YAP, ROCK, β-catenin and Hh signalling.
Public Library of Science
2017
epidermal YAP activity drives GLI 2
basal cell carcinoma
ECM
postnatal tissue homeostasis
YAP 2-5SA mice
control tissue homeostasis
Hedgehog
GLI 2 activity
epidermal β- catenin activation
BCC development
mouse skin
2017-08-18 17:23:56
Figure
https://plos.figshare.com/articles/figure/A_model_outlining_the_cross-regulatory_interactions_between_epidermal_YAP_ROCK_-catenin_and_Hh_signalling_/5325781
<p>(A) Epidermal SmoM2 activates YAP, ROCK signalling and dermal fibroblasts in the dorsal skin of K14-CreER/Rosa-SmoM2 transgenic mice (based on Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.g001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.g002" target="_blank">2</a>). (B) Epidermal YAP activates GLI2 mediated by β-catenin activation in the dorsal skin of YAP2-5SA-ΔC transgenic mice (based on Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.g003" target="_blank">3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.g004" target="_blank">4</a>). (C) A model outlining the proposed regulatory interactions between epidermal YAP, Hedgehog and ROCK-dependent mechanosignalling to balance skin regeneration based on our findings (red arrows) and on cited studies [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref025" target="_blank">25</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref027" target="_blank">27</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref029" target="_blank">29</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref034" target="_blank">34</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref039" target="_blank">39</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref040" target="_blank">40</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref045" target="_blank">45</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref047" target="_blank">47</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref048" target="_blank">48</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref063" target="_blank">63</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref064" target="_blank">64</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref065" target="_blank">65</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref066" target="_blank">66</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref069" target="_blank">69</a>].</p>