10.1371/journal.pone.0183178.g006 Bassem Akladios Bassem Akladios Veronica Mendoza Reinoso Veronica Mendoza Reinoso Jason E. Cain Jason E. Cain Taopeng Wang Taopeng Wang Duncan L. Lambie Duncan L. Lambie D. Neil Watkins D. Neil Watkins Annemiek Beverdam Annemiek Beverdam A model outlining the cross-regulatory interactions between epidermal YAP, ROCK, β-catenin and Hh signalling. Public Library of Science 2017 epidermal YAP activity drives GLI 2 basal cell carcinoma ECM postnatal tissue homeostasis YAP 2-5SA mice control tissue homeostasis Hedgehog GLI 2 activity epidermal β- catenin activation BCC development mouse skin 2017-08-18 17:23:56 Figure https://plos.figshare.com/articles/figure/A_model_outlining_the_cross-regulatory_interactions_between_epidermal_YAP_ROCK_-catenin_and_Hh_signalling_/5325781 <p>(A) Epidermal SmoM2 activates YAP, ROCK signalling and dermal fibroblasts in the dorsal skin of K14-CreER/Rosa-SmoM2 transgenic mice (based on Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.g001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.g002" target="_blank">2</a>). (B) Epidermal YAP activates GLI2 mediated by β-catenin activation in the dorsal skin of YAP2-5SA-ΔC transgenic mice (based on Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.g003" target="_blank">3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.g004" target="_blank">4</a>). (C) A model outlining the proposed regulatory interactions between epidermal YAP, Hedgehog and ROCK-dependent mechanosignalling to balance skin regeneration based on our findings (red arrows) and on cited studies [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref025" target="_blank">25</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref027" target="_blank">27</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref029" target="_blank">29</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref034" target="_blank">34</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref039" target="_blank">39</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref040" target="_blank">40</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref045" target="_blank">45</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref047" target="_blank">47</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref048" target="_blank">48</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref063" target="_blank">63</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref064" target="_blank">64</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref065" target="_blank">65</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref066" target="_blank">66</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183178#pone.0183178.ref069" target="_blank">69</a>].</p>